Increased Renal Aldose Reductase Activity, Immunoreactivity, and mRNA in Streptozocin-Induced Diabetic Rats
نویسندگان
چکیده
منابع مشابه
Rapid Publications Increased Renal Aldose Reductase Activity, Immunoreactivity, and mRNA in Streptozocin-lnduced Diabetic Rats
Increased accumulation of renal sorbitol has been documented in the diabetic rat, and it has been suggested that this accumulation may be important in the pathogenesis of diabetic nephropathy. It is not clear whether sorbitol accumulation results from increases in substrate, activity of the aldose reductase (AR) protein molecule, or activity due to an increase in the amount of enzyme present. I...
متن کاملMelatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat
Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabe...
متن کاملAldose Reductase Inhibitor Ameliorates Renal Vascular Endothelial Growth Factor Expression in Streptozotocin-Induced Diabetic Rats
PURPOSE The vascular endothelial growth factor (VEGF) expression of podocyte is one of the well-known major factors in development of diabetic nephropathy. In this study, we investigated the effects of aldose reductase inhibitor, fidarestat on diabetic nephropathy, and renal VEGF expression in a type 1 diabetic rat model. MATERIALS AND METHODS Twenty four Sprague-Dawley male rats which were p...
متن کاملmelatonin reduces cataract formation and aldose reductase activity in lenses of streptozotocin-induced diabetic rat
background: the relationship between the high activity of aldose reductase (ar) and diabetic cataract formation has been previously investigated. the purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (stz)-induced diabetic cataract in rats. methods: 34 adult healthy male sprague-dawely rats were divided into four groups. diabetic control and diab...
متن کاملAldose reductase gene expression is increased in diabetic nephropathy.
Aldose reductase gene expression is increased in insulin-dependent diabetes mellitus (IDDM) with nephropathy. Epidemiology studies in patients with IDDM and noninsulin-dependent diabetes mellitus (NIDDM) are consistent with the hypothesis that a genetic factor(s) influences the risk for kidney disease of diabetes mellitus (KDDM). Aldose reductase (AR), the rate-limiting enzyme in the polyol pat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 1989
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.38.8.1067